Publications

Books/Chapters
  1. D. Zhou, C. Wang, A. Hert, L. Yan, B. Dou, and L. Ouyang*, in Multicomponent HydrogelsSmart Materials for Biomedical Applications, ed. J. M. Dodda, K. Deshmukh, and D. Bezuidenhout, The Royal Society of Chemistry, 2023, ch. 8, pp. 231-287. [DOI] [PDF]
  1. L. Ouyang*, Study on Microextrusion-based 3D Bioprinting and Bioink Crosslinking Mechanisms (Springer, Singapore, 2019). ISBN 978-981-13-9455-3. [DOI] [PDF]
Journal Articles

(# equal contribution, * corresponding author)

In progress
  1. H.S. Ooi and L. Ouyang* et al., 2026 submitted.
  1. Z. Wang and L. Ouyang* et al., 2026 in revision.
  1. S. Yu and L. Ouyang* et al., 2026 in revision
  1. X. Fu,…J. Na*, 3D Bioprinted Human Vascular Organoid Sheets Promote Functional Ischemic Repair and Exhibit Adaptive In Vivo Remodeling, BMC Medicine (2026), accepted.
2026
  1. B. Dou, D. Zhou, R. Xu, Y. Guo, Z. Wang, L. Ouyang*, Shear-extensional Aspect Programming of Microgels (SHAPE), Advanced Functional Materials (2026), in press. [DOI]
  1. X. Wang#, N. Zhu#, H. Chen#, B. Yu#, X. Gao, H. Li, C. Yang, Y. Ma, M. Qin, Y. Zhang, H. Qi, H. Ding, M. Zhang, X. Sheng, X. Wang, S. Wang, L. Ouyang, Y. Wang, X. Ping*, H. Wang*, L. Zhang*, L. Yin*, 3D-Printed biodegradable and multifunctional cranial device for bone repair and healing assessment, Science Advances (2026), in press. [DOI]
  1. S. Xue, Y. Pang*, Y. Song, R. Liu, C. Xu, H. Zhang, L. Ouyang, W. Sun, F. Lin*, 3D-Printed Mesh-Walled Microtube System Enables a Vascular-Biliary-Incorporated Liver-on-a-Chip, Advanced Functional Materials (2026), in press. [DOI]
  1. D. Zhou#, B. Dou#, S. Fan&, H.S. Ooi&, K. Han, Y. He, X. Zhang, C. Wang, Y. Guo, L. Chen, H. Liu, J. Na, Q. He, H. Wu, Q. Gu, L. Ouyang*, In situ particle-to-fibre transformation of hydrogels for 3D printing, Nature, 656, 879–887(2026). [DOI]
  1. R. Zhang#, X. Wang#*, X. Fu#, L. Ouyang, B. Zhou*, J. Na*, Impact of nanoplastics on human induced pluripotent stem cell-derived endothelial cells and blood vessel organoids, Green Chemical Engineering (2026), in press. [DOI]
2025
  1. A.N. Bismillah et al. 35(+1) challenges in materials science being tackled by PIs under 35(ish) in 2025, Matter, 8, 102565 (2025). [DOI]
  1. F. Perin, L. Ouyang, K.S. Lim, A. Motta, D. Maniglio,L. Moroni, C. Mota*, Bioprinted Constructs in the Regulatory Landscape: CurrentState and Future Perspectives, Advanced Materials, e04037 (2025). [DOI]
  1. C. Wang, Z. Wang, Y. Lin, L. Ouyang*, Off-the-shelf Granular Microtissue Bioinks: Long-term Preserved Cellularized Porous Microgels with Enhanced Cell Activity for Shelf-ready Biofabrication, Advanced Materials, 37, e06616 (2025). [DOI]
  1. J. Ma, Y. Yang, B. Pei, S. Mi*, Z. Xiong*, L. Ouyang*, Primer-Disk-Enabled DNA Data Storage System with Index and Record-Many-Read-Many Features, Advanced Science, 12, e02367 (2025). [DOI]
  1. R. Xu, H. Ooi, L. Bian, L. Ouyang*, W. Sun, Dynamic Hydrogels for Biofabrication: A Review. Biomaterials 320, 123266 (2025) [DOI]
  1. Y. Guo, Z. Wang, X. Zhang, J. Li, S. Gao, Y. Lv, L. Ouyang*, Microfiber-Templated Porogel Bioinks Enable Tubular Interfaces and Microvascularization Down to the Building Blocks for 3D Bioprinting. Small, 2501594 (2025). [DOI] [PDF] [Supporting Information] [Frontispiece]
  1. C. He, J. He, C. Wu et al. 3D printing for tissue/organ regeneration in China. Bio-design and Manufacturing. 8, 169–242 (2025). [DOI]
  1. R. Xu, B. Dou, S. Yu, Z. Wang, Y. Zhang, L. Leng, L. Ouyang*, W. Sun, Enabling 3D printability and vascular morphogenesis with double network dynamic hydrogels. Materials Today, 84, 10-27 (2025). [DOI [PDF] [Supporting Information] [Video 1]
  1. D. Zhou, P. Li, S. Yu, Z. Cui, T. Xu, L. Ouyang*, Optimizing extrusion-based 3D bioprinting of plant cells with enhanced resolution and cell viability. Biofabrication, 17, 025008 (2025).[DOI] [PDF] [Supporting Information]
  1. P. Song, J. Chen, D. Zhao, K. Shi, R. Xu, M. Zhu, L. Zhao*, E.T. Pashuck, L. Ouyang, F. Jiao, Y. Lin*, Evolving Emulsion Microcompartments viaEnzyme-Mimicking Amyloid-Mediated Interfacial Catalysis. Small, 21, 2409601 (2025). [DOI] [PDF] [Supporting Information]
  1. B. Pei, J. Ma, L. Ouyang, Z. Xiong*, High-Security Data Encryption Enabled by DNA Multi-Strand Solid-Phase Hybridization and Displacement in Inkjet-Printed Microarrays. ACS Applied Materials & Interfaces, 17, 6, 10179–10190 (2025). [DOI] [PDF] [Supporting Information]
  1. CK Chua*, J. An, S. Fan, X. Zhang, L. Ouyang*, H. Liu, L. Zhang, Y. Ren, M. Gou*, WL Ng, WY Yeong*, H. Zhu, Z. Meng, J. He*, A perspective on transformative bioprinting. International Journal of Bioprinting, 11(1), 1–29 (2025). [DOI]
2024
  1. B. Pei, Y. Zhou, Y. Yang, J. Ma, R. Cao, W. Huang, L. Ouyang, S. Mi, Z. Xiong*, A Novel DNA-based dual-mode data storage system with interrelated concise and detailed data. Small Science, 4, 2400094 (2024). [DOI] [PDF] [Supporting Information]
  1. X. Jia, X. Fan, C. Chen, Q. Lu, H. Zhou, Y. Zhao, X. Wang, S. Han, L. Ouyang, H. Yan, H. Dai*, H. Geng*, Chemical and structural engineering of gelatin-based delivery systems for therapeutic applications: a review. Biomacromolecules 25, 564-589 (2024). [DOI][PDF]
  1. Z. Zhou, J. Ji, J. He, T. Liu, L. Ouyang, W. Zhang, X. Zhang, Z. Zhang, K. Zhang, Y. Pang*, W. Sun*,  Harnessing three-dimensional in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies. Nature Reviews Immunology 24, 18-32 (2024). [DOI][PDF]
2023
  1. L. Ouyang*, M. Salmeron-Sanchez, Editorial 3D bioprinting and advanced biofabrication of biomaterials. Biomaterials Advances 156, 213725 (2023). [DOI][PDF]
  1. D. Zhou, B. Dou, F. Kroh, C. Wang, L Ouyang*, Biofabrication strategies with single-cell resolution: a review. International Journal of Extreme Manufacturing 5, 042005 (2023). [DOI][PDF]
  1. M. Ye, Y Shan, B Lu, H Luo, B Li, Y Zhang, Z Wang, Y Guo, L Ouyang, J Gu, Z Xiong*, T Zhang*, Creating a semi-opened micro-cavity ovary through sacrificial microspheres as an in vitro model for discovering the potential effect of ovarian toxic agents. Bioactive Materials 26, 216-230 (2023). [DOI][PDF][Supporting Information]
  1. P. Li, D. Zhou, C. Yang, W. Rao, F. Lin, L. Ouyang*, Advances in 3D Bioprinting: Additive Manufacturing of Living Cells from Animal, Plant, and Microbe. Journal of Mechanical Engineering 59, 237-252 (2023) [DOI][PDF]
2022
  1. D. Hachim, J. Zhao, J. Bhankharia, R. Nuñez-Toldra, L. Brito, H. Seong, M. Becce, L. Ouyang, C.L. Grigsby, S.G. Higgins, C.M. Terracciano, M.M. Stevens, Polysaccharide-polyplex nanofilm coatings enhance nanoneedle-based gene delivery and transfection efficiency. Small 18, 2202303 (2022). [DOI][PDF][Supporting Information]
  1. Y. Yang#, R. Xu#, C. Wang, Y. Guo, W. Sun*, L. Ouyang*, Recombinant Human Collagen-Based Bioinks for the 3D bioprinting of Full-thickness Human Skin Equivalent and Skin Tissue Engineering. International Journal of Bioprinting 8, 611 (2022). [DOI][PDF][Supporting Information]
  1. X. Mo, L. Ouyang, Z. Xiong*, T. Zhang*, Advances in Digital Light Processing of Hydrogels. Biomedical Materials 17, 042002 (2022). [DOI][PDF]
  1. C. Wang, Y. Yang, J. Ji, Y. Fang, L. Ouyang, L. Zhang*, W. Sun*, 3D-printed bioresorbable stent coated with dipyridamole-loaded nanofiber for restenosis prevention and endothelialization. International Journal of Bioprinting 8, 543 (2022). [DOI][PDF]
  1. X. Tian*, L. Wu, D. Gu, S. Yuan, Y. Zhao, X. Li, L. Ouyang, B. Song, T. Gao, J. He, X. Lin, F. Lin, J. Zhu, D. Li*, Roadmap for Additive Manufacturing: toward Intellectualization and Industrialization. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers (CJME-AMF) 1, 100014 (2022). [DOI] [PDF]
  1. Y. Fang#, Y. Guo#, T. Liu, R. Xu, S. Mao, X. Mo, T. Zhang, L. Ouyang*, Z. Xiong*, W. Sun, Advances in 3D Bioprinting. Chinese Journal of Mechanical Engineering: Additive Manufacturing Frontiers (CJME-AMF) 1, 100011 (2022). [DOI] [PDF]
  1. L. Ouyang*, J.P. Wojciechowski, J. Tang, Y. Guo, M.M. Stevens*, Tunable Microgel-Templated Porogel (MTP) Bioink for 3D Bioprinting Applications, Advanced Healthcare Materials, 11, 2200027 (2022). [DOI] [PDF] [Supporting Information] [Video1] Front Cover This Month in Pictures Feb 2022 Advanced Scinece News
  1. L. Ouyang*, Pushing the Rheological and Mechanical Boundaries of Extrusion-based 3D Bioprinting. Trends in Biotechnology, 40, 891-902 (2022). [DOI] [PDF] [Video1]
  1. H. Zhu, M. Monavari, K. Zheng, T. Distler, L. Ouyang, S. Heid, Z. Jin, J. He, D. Li, A.R. Boccaccini*, 3D Bio-printing of Multi-functional Dynamic Nanocomposite Bioinks incorporating Cudoped mesoporous bioactive glass nanoparticles for Bone Tissue Engineering. Small, 18, 2104996 (2022). [DOI] [PDF] [Supporting Information] [Video1] [Video2]
  1. Z. Fu, L. Ouyang*, R. Xu, Y. Yang, W. Sun*, Responsive Biomaterials for 3D Bioprinting: A Review. Materials Today 52, 112-132 (2022). [DOI] [PDF] Highlighted Paper
2021
  1. H. Hajiali*, L. Ouyang, V. Llopis-Hernandez, O. Dobred, F.R.A.J. Rose*, Review of Emerging Nanotechnology in Bone Regeneration: Progress, Challenges, and Perspectives. Nanoscale 13, 10266-10280 (2021). [DOI] [PDF]
  1. C. Li#, L. Ouyang#, J.P.K. Armstrong*, M.M. Stevens*, Advances in the Fabrication of Biomaterials for Gradient Tissue Engineering. Trends in Biotechnology 39, 150-164 (2021). [DOI] [PDF]
Before 2020
  1. Y. Fang, L. Ouyang, T. Zhang*, C. Wang, B. Lu, W. Sun, Optimizing Bifurcated Channels within an Anisotropic Scaffold for Engineering Vascularized Oriented Tissues. Advanced Healthcare Materials 9, 2000782 (2020). [DOI] [PDF] [Supporting Information]
  1. L. Ouyang, J.P.K. Armstrong, Y. Lin, J.P. Wojciechowski, C. Lee-Reeves, D. Hachin, K. Zhou, J.A. Burdick, M.M. Stevens*, Expanding and Optimizing 3D Bioprinting Capabilities using Complementary Network Bioinks. Science Advances 6, eabc5529 (2020). [DOI] [PDF] [Supporting Information]
  1. L. Ouyang, J.P.K. Armstrong, M. Salmeron‐Sanchez, M.M. Stevens*, Assembling Living Building Blocks to Engineer Complex Tissues. Advanced Functional Materials 30, 1909009 (2020). [DOI] [PDF]
  1. L. Ouyang, J.P.K. Armstrong, Q. Chen, Y. Lin, M.M. Stevens*, Void‐Free 3D Bioprinting for In Situ Endothelialization and Microfluidic Perfusion. Advanced Functional Materials 30, 1908349 (2020). [DOI] [PDF] [Supporting Information] [Video1] [Video2] [Video3] [Video4]
  1. C. Li, L. Ouyang, I.J. Pence, A.C. Moore, Y. Lin, C.W. Winter, J.P.K. Armstrong*, M.M. Stevens*, Buoyancy‐Driven Gradients for Biomaterial Fabrication and Tissue Engineering, Advanced Materials 31, 1900291 (2019). [DOI] [PDF] [Supporting Information] [Video1]
  1. L. Ouyang, J.A. Burdick, W. Sun*, Facile Biofabrication of Heterogeneous Multilayer Tubular Hydrogels by Fast Diffusion-induced Gelation. ACS Applied Materials & Interfaces 10, 12424-12430 (2018). [DOI] [PDF] [Supporting Information] [Video1]
  1. L. Ouyang, C.B. Highley, W. Sun, J.A. Burdick*, A Generalizable Strategy for The 3D Bioprinting of Hydrogels From Nonviscous Photo‐Crosslinkable Inks. Advanced Materials 29, 1604983 (2017). [DOI] [PDF] [Supporting Information] [Video1] [Video2] [Video3] [Video4] [Video5]
  1. Y.C. Yeh, L. Ouyang, C.B. Highley, J.A. Burdick*, Norbornene-modified Poly (glycerol sebacate) as A Photocurable and Biodegradable Elastomer. Polymer Chemistry 8, 5091-5099 (2017). [DOI] [PDF] [Video1]
  1. Y.C. Yeh#, C.B. Highley#, L. Ouyang, J.A. Burdick*, 3D Printing of Photocurable Poly (glycerol sebacate) Plastomers. Biofabrication 8, 045004 (2016). [DOI] [PDF]
  1. L. Ouyang#, C.B. Highley#, C.B. Rodell, W. Sun, J.A. Burdick*, 3D Printing of Shear-thinning Hyaluronic Acid Hydrogels with Secondary Cross-linking. ACS Biomaterials Science & Engineering 2, 1743-1751 (2016). [DOI] [PDF] [Supporting Information]
  1. L. Ouyang, R. Yao*, Y. Zhao, W. Sun, Effect of Bioink Properties on Printability and Cell Viability for 3D Bioplotting of Embryonic Stem Cells. Biofabrication 8, 035020 (2016). [DOI] [PDF] [Supporting Information]
  1. L. Ouyang#, R. Yao#, S. Mao, X. Chen, J. Na, W. Sun*, Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation. Biofabrication 7, 044101 (2015). [DOI] [PDF]
  1. L. Ouyang#, R. Yao#, X. Chen#, J. Na*, W. Sun*, 3D printing of HEK 293FT cell-laden hydrogel into macroporous constructs with high cell viability and normal biological functions. Biofabrication 7, 015010 (2015). [DOI] [PDF]
  1. Y. Zhao#, R. Yao#, L. Ouyang, H. Ding, T. Zhang, K. Zhang, S. Cheng, W. Sun*, Three-dimensional printing of Hela cells for cervical tumor model in vitro. Biofabrication 6, 035001 (2014). [DOI] [PDF]
  1. T. Zhang*, K.C. Yan, L. Ouyang, W. Sun, Mechanical Characterization of Bioprinted In Vitro Soft Tissue Models. Biofabrication 5, 045010 (2013). [DOI] [PDF]

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